134 The role of gut microbiota-derived metabolites in psoriasis

Gut microbiome alterations observed in patients with psoriasis might contribute to the disease pathogenesis through an increased intestinal permeability and translocation of several bacterial metabolites. The aim study was assess gut barrier dysfunction, concentration microbiota-derived metabolites their possible association clinical manifestations comorbidities psoriasis. One hundred twenty moderate severe plaque as well 60 age- weight-matched control were enrolled. Intestinal damage assessed based on plasma markers its integrity (claudine-3, fatty acid binding protein) - trimethylamine (TMA), oxide (TMAO), p-cresyl sulfate (pCS), indoxyl (IS). Concentrations claudine-3 protein determined by ELISA, while concentrations high-performance liquid chromatography. severity gastrointestinal symptoms a validated version international GSRS questionnaire. characteristics pruritus using visual analog scale. Patients characterized higher (52.4 vs 43.5 ng/ml), (256.2 134.8 pg/ml), TMA (1392.1 861.4 TMAO (327.9 195.7 pCS (4.35 1.93 ug/ml), IS (989.7 528.4 ng/ml). Factors affecting high activity smoking. damaged reported more intense symptoms. positively correlated inflammatory biomarkers, cardiovascular risk, metabolic syndrome. Psoriasis promotes disruption gut-derived leading dysregulation multiple pathogenetic pathways skin, joints, blood vessels adipose tissue.